FEATURES

FAMILY

DESCRIPTION

Also known as PPCEL_HUMAN, PREPL, KIAA0436. Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330). Homodimer (PubMed:16143824). Interacts with the AP-1 complex (PubMed:23321636).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PREPL

Prolyl endopeptidase-like

PREPL

Molecular Synopsis