FEATURES

FAMILY

DESCRIPTION

Also known as AMOT_HUMAN, AMOT, KIAA1071. Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AMOT

Mutations

Mutation(s) distribution

Mutations table