FEATURES

DESCRIPTION

Also known as AGDP1_ARATH, AGDP1, ADCP1. Heterochromatin-binding protein that preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, whith a stronger affinity for dimethylated H3K9 (H3K9me2) (PubMed:30382101, PubMed:30425322). Required for transcriptional silencing, non-CG DNA methylation (e.g. CHG and CHH regions), and H3K9 dimethylation (H3K9me2) at some loci (PubMed:30382101, PubMed:30425322). Mediates heterochromatin phase separation and chromocenter formation (PubMed:30425322).

EXTERNAL LINKS

uniprot
enzyme classification

AGDP1

Protein AGENET DOMAIN (AGD)-CONTAINING P1

Mutations

Mutation(s) distribution

Mutations table

Search Mutation