FEATURES

FAMILY

pyridoxamine 5'-phosphate oxidase family

DESCRIPTION

Also known as PHZG_PSEFL, phzG. Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control (PubMed:9573209, PubMed:23897464). Catalyzes several oxidations in the terminal steps of core phenazine biosynthesis. It oxidizes both hexahydrophenazine-1, 6-dicarboxylic acid (HHPDC) and tetrahydrophenazine-1-carboxylic acid (THPCA) and thereby contributes to the generation of both phenazine-1, 6-dicarboxylic acid (PDC) and phenazine-1-carboxylic acid (PCA). It synthesizes phenazines in their reduced form, which are the likely end products in vivo (PubMed:23897464). Homodimer.

EXTERNAL LINKS

phzG

Dihydrophenazinedicarboxylate synthase

phzG

Molecular Synopsis