FEATURES

FAMILY

DESCRIPTION

Also known as BAPA_SPHXN, bapA. Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar. Heterooctamer of 4 heterodimers ((alpha:beta)4); each heterodimer is composed of an alpha subunit and a beta subunit processed from the same precursor.

EXTERNAL LINKS

bapA

Beta-peptidyl aminopeptidase BapA

bapA

Molecular Synopsis