FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHB12_HUMAN, HSD17B12, SDR12C1. Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. Interacts with ELOVL1 and LASS2.

EXTERNAL LINKS

HSD17B12

Very-long-chain 3-oxoacyl-CoA reductase

Mutations

Mutation(s) distribution

Mutations table

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