FEATURES

FAMILY

DESCRIPTION

Also known as TYW2_HUMAN, TRMT12, TRM12, TYW2. S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRMT12

tRNA wybutosine-synthesizing protein 2 homolog

TRMT12

Molecular Synopsis