FEATURES

FAMILY

DESCRIPTION

Also known as DNRF_STREF, rdmE. Involved in the biosynthesis of the anthracyclines carminomycin, rhodomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the incorporation of a hydroxyl group at position C-11 of aklavinone, resulting in epsilon-rhodomycinone. It cannot accept substrates glycosylated at position C-7 and is specific for the C-9R configuration of anthracyclines. It can use both NAD or NADP but it is slowly inactivated in the presence of NADH. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

rdmE

Aklavinone 12-hydroxylase RdmE

rdmE

Molecular Synopsis