FEATURES

FAMILY

DESCRIPTION

Also known as PHB2_DICDI, phbB. Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus., In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan., In the nucleus, serves as transcriptional co-regulator. The mitochondrial prohibitin complex consists of two subunits (PHB and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.

EXTERNAL LINKS

phbB

Prohibitin-2

phbB

Molecular Synopsis