FEATURES

FAMILY

DESCRIPTION

Also known as PAN3_HUMAN, PAN3. Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. Homodimer (PubMed:23932717). Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex (PubMed:14583602, PubMed:23932717). Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex (PubMed:17595167, PubMed:18056425). Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6 (PubMed:21981923). Interacts with YTHDF3 (By similarity).

EXTERNAL LINKS

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

PAN3

Structural Ligandability

Domains Chains

Distribution