FEATURES

FAMILY

DESCRIPTION

Also known as SDK2_HUMAN, SDK2, KIAA1514. Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SDK2

Protein sidekick-2

SDK2

Molecular Synopsis