FEATURES

FAMILY

DESCRIPTION

Also known as RETR1_RAT, Retreg1, Fam134b. Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons. Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2.

EXTERNAL LINKS

uniprot
enzyme classification

Retreg1

Reticulophagy regulator 1

Retreg1

Structural Ligandability

Domains Chains

Distribution