FEATURES

FAMILY

DESCRIPTION

Also known as COF2_PIG, CFL2. Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

CFL2

Cofilin-2

CFL2

Structural Ligandability

Domains Chains

Distribution