phactr4-a (Phosphatase and actin regulator 4-A)
FEATURES
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ORGANISM
Xenopus laevis
FAMILY
DESCRIPTION
Also known as PHR4A_XENLA, phactr4-a. Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). Binds ppp1ca and actin.
Also known as PHR4A_XENLA, phactr4-a. Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell prolifer
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phactr4-a

Phosphatase and actin regulator 4-A

Molecular Synopsis