FEATURES

DESCRIPTION

Also known as PAF15_XENLA, pclaf, paf. PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). Interacts with pcna.

EXTERNAL LINKS

uniprot
enzyme classification

pclaf

PCNA-associated factor

pclaf

Structural Ligandability

Domains Chains

Distribution