FEATURES

FAMILY

DESCRIPTION

Also known as NUBP1_RAT, Nubp1. Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure. Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with the BBS/CCT complex subunit CCT1.

EXTERNAL LINKS

uniprot
enzyme classification

Nubp1

Cytosolic Fe-S cluster assembly factor NUBP1

Nubp1

Structural Ligandability

Domains Chains

Distribution