ACTPG (DELTA-actitoxin-Oor1b)
FEATURES
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ORGANISM
Oulactis orientalis
FAMILY
DESCRIPTION
Also known as ACTPG_OULOR, ACTPG. Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects (By similarity). Tetramer in the presence of a lipidic interface. Monomer, in soluble state (By similarity).
Also known as ACTPG_OULOR, ACTPG. Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjace
ACTPG logo

ACTPG

DELTA-actitoxin-Oor1b

Molecular Synopsis