FEATURES

DESCRIPTION

Also known as NBN_DANRE, nbn, nbs1. Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (By similarity). Component of the MRN complex composed of two heterodimers rad50/mre11 associated with a single nbn.

EXTERNAL LINKS

uniprot
enzyme classification

nbn

Nibrin

nbn

Molecular Synopsis