FEATURES

FAMILY

DESCRIPTION

Also known as TGIF1_PANTR, TGIF1, TGIF. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity). Interacts with SMAD2 (By similarity). Interacts with CTBP, SMAD3 and HDAC1.

TGIF1

Structural Ligandability

Domains Chains

Distribution