FEATURES

FAMILY

DESCRIPTION

Also known as MON1_ORYSJ, MON1. Plays an important role in membrane trafficking through the secretory apparatus. In complex with CCZ1, acts as a guanine exchange factor (GEF) for Rab7 protein family. Promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. The active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation. Interacts with CCZ1A, CCZ1B and RABF2B.

EXTERNAL LINKS

uniprot
enzyme classification

MON1

Vacuolar fusion protein MON1 homolog

MON1

Structural Ligandability

Domains Chains

Distribution