FEATURES

FAMILY

DESCRIPTION

Also known as CLN5_CANLF, CLN5. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Interacts with SORT1, RAB5A and RAB7A. Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B.

EXTERNAL LINKS

uniprot
enzyme classification

CLN5

Ceroid-lipofuscinosis neuronal protein 5

CLN5

Structural Ligandability

Domains Chains

Distribution