FEATURES

FAMILY

DESCRIPTION

Also known as H2AL1_MOUSE, H2al1a, H2al1c, H2al1d, H2al1f, H2al1g, H2al1h, H2al1i. Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847).

EXTERNAL LINKS

H2al1a, H2al1c, H2al1d, H2al1f, H2al1g, H2al1h, H2al1i

Histone H2A-like 1

H2al1a, H2al1c, H2al1d, H2al1f, H2al1g, H2al1h, H2al1i

Molecular Synopsis