FEATURES

FAMILY

DESCRIPTION

Also known as M21_MPV15, M2-1. Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Homotetramer. The homotetramer interacts with RNA. Interacts with the phosphoprotein (P); this interaction is required for protein M2-1 function, localization in host inclusion bodies. Formation of a complex host PP1/M2-1/P allows P to target host PP1 phosphatase to the M2-1 substrate. Interacts with the nucleoprotein (N). Interacts with the matrix protein (M); this interaction directs M localization to cytoplasmic inclusions comprising viral proteins L, N, P, and M2-1 and mediates M association with the nucleocapsid. Interacts with host PABPC1 (via C-terminus).

EXTERNAL LINKS

M2-1

Protein M2-1

M2-1

Molecular Synopsis