FEATURES

FAMILY

DESCRIPTION

Also known as GRHL1_PONAB, GRHL1. Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Binds DNA as homodimer. Homodimer, also forms heterodimers with GRHL2 or GRHL3.

EXTERNAL LINKS

uniprot
enzyme classification

GRHL1

Grainyhead-like protein 1 homolog

GRHL1

Structural Ligandability

Domains Chains

Distribution