FEATURES

FAMILY

DESCRIPTION

Also known as FA83B_HUMAN, FAM83B, C6orf143. Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. Interacts with EGFR; the interaction is disrupted by EGF stimulation (PubMed:23912460). Interacts with RAF1; displaces 14-3-3 proteins from RAF1 and activates RAF1 within the RAS/MAPK signaling cascade (PubMed:22886302). Interacts with AKT1, PIK3CA and PIK3R1; activates the PI3K/AKT signaling cascade (PubMed:23676467).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FAM83B

Protein FAM83B

FAM83B

Molecular Synopsis