FEATURES

FAMILY

DESCRIPTION

Also known as THEM4_HUMAN, THEM4, CTMP. Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Homodimer and homotetramer. Interacts with AKT1 in the cytosol.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

THEM4

Acyl-coenzyme A thioesterase THEM4

THEM4

Molecular Synopsis