FEATURES

FAMILY

DESCRIPTION

Also known as OBSCN_HUMAN, OBSCN, KIAA1556, KIAA1639. Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3, 4-bisphosphate (PtdIns(3, 4)P2) and phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) (PubMed:28826662). Interacts (via protein kinase domain 2) with CDH2 and (via protein kinase domain 1) with ATP1B1 (By similarity). Isoform 3 interacts with TTN/titin and calmodulin (PubMed:11448995, PubMed:11717165). Isoform 3 interacts with ANK1 isoform Mu17/ank1.5 (PubMed:12527750).

EXTERNAL LINKS

OBSCN

Obscurin

OBSCN

Molecular Synopsis