FEATURES

FAMILY

DESCRIPTION

Also known as NTM1B_HUMAN, NTMT2, C1orf184, METTL11B, NRMT2. Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352).

Also known as NTM1B_HUMAN, NTMT2, C1orf184, METTL11B, NRMT2. Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when ...

EXTERNAL LINKS

NTMT2

N-terminal Xaa-Pro-Lys N-methyltransferase 2

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

NTMT2

Structural Ligandability

Domains Chains

Distribution