FEATURES

FAMILY

DESCRIPTION

Also known as TET5C_HUMAN, TENT5C, FAM46C. Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death., (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon. Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TENT5C

Terminal nucleotidyltransferase 5C

TENT5C

Molecular Synopsis