FEATURES

FAMILY

DESCRIPTION

Also known as FBX31_HUMAN, FBXO31, FBX14, FBX31. Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXO31

F-box only protein 31

FBXO31

Molecular Synopsis