FEATURES

FAMILY

DESCRIPTION

Also known as CRFR2_MOUSE, Crhr2, Crf2r. G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Monomer. Interacts with CRF, UCN, UCN2 and UCN3 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Crhr2

Corticotropin-releasing factor receptor 2

Mutations

Mutation(s) distribution

Mutations table

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