FEATURES

FAMILY

DESCRIPTION

Also known as MARE1_MOUSE, Mapre1. Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). May play a role in cell migration (PubMed:15311282). Homodimer (By similarity). Heterodimer with MAPRE3 (By similarity). Interacts with APC (via C-terminal domain), DCTN1, DIAPH1, DIAPH2 (PubMed:15311282). Interacts with DCTN2, TERF1 and dynein intermediate chain (By similarity). Interacts with CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends (By similarity). Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules (By similarity). Interacts with APC2 (By similarity). Interacts with CLASP1 (By similarity). Interacts (via C-terminus) with CLIP1 (By similarity). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with MACF1 (PubMed:18854161). Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends (By similarity). Interacts with MISP (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (PubMed:23055941). Interacts with KCNAB2 (PubMed:21357749). Interacts with KNSTRN (By similarity). Interacts with NCKAP5L (By similarity). Interacts with AKAP9 (By similarity). Interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus. May form a pericentrosomal complex with AKAP9, CDK5RAP2 and PDE4DIP isoform 2/MMG8/SMYLE; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (By similarity). Contrary to other mammalian species, does not interact with CDK5RAP2, possibly due to the lack of conservation of the MAPRE1-binding motif in mouse CDK5RAP2 (PubMed:19553473). Interacts with AKNA (PubMed:30787442). Interacts with GAS2L1, GAS2L2, and GAS2L3 (PubMed:24706950). Interacts with RARRES1 and AGBL2 (By similarity).

EXTERNAL LINKS

Mapre1

Mutations

Mutation(s) distribution

Mutations table