FEATURES

FAMILY

DESCRIPTION

Also known as I10R2_MOUSE, Il10rb, Crfb4. Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). Heterodimer with IFNLR1.

Also known as I10R2_MOUSE, Il10rb, Crfb4. Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a rece ...

EXTERNAL LINKS

uniprot
enzyme classification

Il10rb

Mutations

Mutation(s) distribution

Mutations table