FEATURES

FAMILY

DESCRIPTION

Also known as EPHA6_MOUSE, Epha6, Ehk-2, Ehk2. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via SAM domain) with ANKS1A (via SAM domain) (PubMed:29749928).

EXTERNAL LINKS

Epha6

Mutations

Mutation(s) distribution

Mutations table