FEATURES

FAMILY

DESCRIPTION

Also known as GFRA1_RAT, Gfra1, Gdnfra, Retl1, Trnr1. Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET (PubMed:15044950). Interacts with RET (By similarity). Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Gfra1

Mutations

Mutation(s) distribution

Mutations table