FEATURES

FAMILY

DESCRIPTION

Also known as ACOHC_RAT, Aco1, Ireb1, Irebp. Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:16144863). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:16144863)., Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).

EXTERNAL LINKS

Aco1

Cytoplasmic aconitate hydratase

Aco1

Molecular Synopsis