FEATURES

FAMILY

DESCRIPTION

Also known as CANB1_MOUSE, Ppp3r1, Cnb. Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:26794871). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). The regulatory subunit confers calcium sensitivity. Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:26794871). Interacts with catalytic subunit PPP3CB/calcineurin A (By similarity). Isoform 1 and isoform 2 interact with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy (PubMed:20639889).

Also known as CANB1_MOUSE, Ppp3r1, Cnb. Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Forms a complex composed of ...

EXTERNAL LINKS

Ppp3r1

Calcineurin subunit B type 1

Ppp3r1

Molecular Synopsis