FEATURES

FAMILY

DESCRIPTION

Also known as MP2K2_MOUSE, Map2k2, Mek2, Mkk2, Prkmk2. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (PubMed:19219045). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Interacts with MORG1 (PubMed:15118098). Interacts with SGK1 (By similarity). Interacts with KSR1 (PubMed:10409742). Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization (By similarity). Interacts with GLS (By similarity).

EXTERNAL LINKS

Map2k2

Dual specificity mitogen-activated protein kinase kinase 2

Map2k2

Molecular Synopsis