FEATURES

FAMILY

DESCRIPTION

Also known as GLND_BURPS, glnD. Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.

EXTERNAL LINKS

uniprot
enzyme classification

glnD

Bifunctional uridylyltransferase/uridylyl-removing enzyme

glnD

Structural Ligandability

Domains Chains

Distribution