FEATURES

FAMILY

class-I aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as SYI1_BURPS, ileS1. Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

ileS1

Isoleucine--tRNA ligase 1

ileS1

Molecular Synopsis