FEATURES

FAMILY

DESCRIPTION

Also known as SAE2A_XENLA, uba2-a, sae2-a, uble1b-a. The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Heterodimer of sae1 and uba2/sae2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with ube2i (By similarity).

Also known as SAE2A_XENLA, uba2-a, sae2-a, uble1b-a. The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation ...

EXTERNAL LINKS

uniprot
enzyme classification

uba2-a

SUMO-activating enzyme subunit 2-A

uba2-a

Structural Ligandability

Domains Chains

Distribution