uba2-a (SUMO-activating enzyme subunit 2-A)

FEATURES

FAMILY

DESCRIPTION

Also known as SAE2A_XENLA, uba2-a, sae2-a, uble1b-a. The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Heterodimer of sae1 and uba2/sae2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with ube2i (By similarity).

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EXTERNAL LINKS

uba2-a

SUMO-activating enzyme subunit 2-A

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Molecular Synopsis
Structural Ligandability

uba2-a

Structural Ligandability

Domains Chains

Distribution