FEATURES

FAMILY

DESCRIPTION

Also known as DUS6_RAT, Dusp6, Mkp3. Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Interacts with MAPK1/ERK2.

EXTERNAL LINKS

uniprot
enzyme classification

Dusp6

Dual specificity protein phosphatase 6

Dusp6

Molecular Synopsis