FEATURES

FAMILY

class-III pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as AGT2_RAT, Agxt2, Agt2. Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

Agxt2

Alanine--glyoxylate aminotransferase 2, mitochondrial

Agxt2

Structural Ligandability

Domains Chains

Distribution