FEATURES

FAMILY

DESCRIPTION

Also known as EST1F_RAT, Ces1f. Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (PubMed:12230550). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Ces1f

Liver carboxylesterase 1F

Ces1f

Structural Ligandability

Domains Chains

Distribution