FEATURES

FAMILY

DESCRIPTION

Also known as TA2R4_PONPY, TAS2R4. Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

TAS2R4

Taste receptor type 2 member 4

TAS2R4

Structural Ligandability

Domains Chains

Distribution