FEATURES

FAMILY

DESCRIPTION

Also known as UD15_RAT, Ugt1a5, Ugt1. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II. Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.

EXTERNAL LINKS

uniprot
enzyme classification

Ugt1a5

UDP-glucuronosyltransferase 1A5

Ugt1a5

Molecular Synopsis