FEATURES

FAMILY

DESCRIPTION

Also known as CAN3_MOUSE, Capn3. Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-410'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.

EXTERNAL LINKS

uniprot
enzyme classification

Capn3

Calpain-3

Capn3

Structural Ligandability

Domains Chains

Distribution