FEATURES

FAMILY

DESCRIPTION

Also known as ILVC_UNCAG, ilvC. Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2, 3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2, 3-dihydroxy-isovalerate. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

ilvC

Ketol-acid reductoisomerase (NAD(+))

Mutations

Mutation(s) distribution

Mutations table

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