FEATURES

FAMILY

DESCRIPTION

Also known as STEA3_HUMAN, STEAP3, TSAP6. Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

STEAP3

Mutations

Mutation(s) distribution

Mutations table