FEATURES

FAMILY

DESCRIPTION

Also known as ATG9B_HUMAN, ATG9B, APG9L2, NOS3AS. Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.

EXTERNAL LINKS

ATG9B

Autophagy-related protein 9B

ATG9B

Molecular Synopsis